article information

Journal of Kermanshah University of Medical Sciences: Vol.18, issue 1; e74276
published online: April 29, 2014
article type: Brief Report
received: August 26, 2013
accepted: January 28, 2014
DOI: https://doi.org/10.22110/jkums.v18i1.1320
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High risk of birth defects with PKU in Mast-e Ali village, Kermanshah province

authors:

avatar Keyvan Moradi 1 , avatar Reza Alibakhshi 2 , *

Dept. of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Dept. of Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

how to cite: Moradi K, Alibakhshi R. High risk of birth defects with PKU in Mast-e Ali village, Kermanshah province. J Kermanshah Univ Med Sci. 2014;18(1):e74276. https://doi.org/10.22110/jkums.v18i1.1320.

Abstract

According to the study conducted on phenylketonuria (PKU) patients in Kermanshah province, there were at least 10 PKU patients in Firuzabad district. The prevalence of the disease and frequency of carriers among the population of Mast-e Ali village, a village in Firuzabad district, were calculated to be 1 in 80 and 1 in 5, respectively. This is one of the highest frequencies reported for the prevalence of PKU to date. These findings introduce Mast-e Ali village as a small region in the high risk of birth defects with PKU. It seems that consanguinity has had a major impact on these findings.

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