Abstract
Background: Ischemic left ventricular (LV) dysfunction is one of the major causes of LV dyssynchrony. This
is indicative of poor prognosis in patients with LV dysfunction and correction of ischemia by Coronary Artery
Bypass Grafting (CABG) may resynchronize LV contraction. The aim of this study was to evaluate the effect of
CABG on LV dyssynchrony, systolic and diastolic function.
Patients: The present study comprised 31 patients with ischemic LV dysfunction with Ejection Fraction (EF:25-
50%). Echocardiography with Tissue Doppler Imaging (TDI) was performed to assess LV dyssynchrony (calculated
by basal LV segment),to evaluate diastolic function by measurement of peak early diastolic mitral annular
velocity (Em) ,systolic function by measurement of peak early systolic mitral annular velocity (Sm) and Ejection
Fraction (EF) by Simpson method.
Results: Mean LV dyssychrony before CABG was 30±16 ms that decreased to 22±14 ms after operation
(P=0.04).There was also improved diastolic and systolic function after CABG ( Em 0.04m/s versus 0.05 m/s ,
P=0.01 and Sm 0.06 m/s versus 0.08 m/s P=0.01).The mean ejection fraction rose from 40±8.6% to 42±8.2%
(P=0.01).
Conclusion: CABG is associated with improvement of LV dyssynchrony, systolic and diastolic function in
patients with ischemic LV dysfunction.
is indicative of poor prognosis in patients with LV dysfunction and correction of ischemia by Coronary Artery
Bypass Grafting (CABG) may resynchronize LV contraction. The aim of this study was to evaluate the effect of
CABG on LV dyssynchrony, systolic and diastolic function.
Patients: The present study comprised 31 patients with ischemic LV dysfunction with Ejection Fraction (EF:25-
50%). Echocardiography with Tissue Doppler Imaging (TDI) was performed to assess LV dyssynchrony (calculated
by basal LV segment),to evaluate diastolic function by measurement of peak early diastolic mitral annular
velocity (Em) ,systolic function by measurement of peak early systolic mitral annular velocity (Sm) and Ejection
Fraction (EF) by Simpson method.
Results: Mean LV dyssychrony before CABG was 30±16 ms that decreased to 22±14 ms after operation
(P=0.04).There was also improved diastolic and systolic function after CABG ( Em 0.04m/s versus 0.05 m/s ,
P=0.01 and Sm 0.06 m/s versus 0.08 m/s P=0.01).The mean ejection fraction rose from 40±8.6% to 42±8.2%
(P=0.01).
Conclusion: CABG is associated with improvement of LV dyssynchrony, systolic and diastolic function in
patients with ischemic LV dysfunction.
Keywords
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Copyright
© 2009, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.