Pathology and Prognosis of Colorectal Cancer


avatar Azadeh Safaee 1 , * , avatar B Moghimi-dehkordi 1 , avatar SR Fatemi 1 , avatar S Ghiasi 1 , avatar MR Zali 1

1 Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University (M.C), Iran

How to Cite: Safaee A , Moghimi-dehkordi B, Fatemi S, Ghiasi S, Zali M. Pathology and Prognosis of Colorectal Cancer. Int J Cancer Manag. 2009;2(3):e80570.


International Journal of Cancer Management: 2 (3); e80570
Published Online: September 30, 2009
Article Type: Research Article
Received: September 30, 2009
Accepted: September 30, 2009


Introduction: Colorectal cancer (CRC) is one of the most common cancers in the world. During the past decades, survival of colorectal cancer patients has improved worldwide, however, it is not clear what factors have contributed to this development. This study was designed to evaluate the prognostic impact of a wide spectrum of pathologic parameters on survival rate in patients with colorectal cancer.

Methods: 1127 patients with colorectal cancer who registered in one cancer registry in Iran were followed from their diagnostic date to Jan 1, 2007 (as failure time). Overall survival time was calculated by Kaplan-Meier method. The Cox proportional hazard model was used to identify the pathologic factors that could independently influence survival.

Results: The overall survival rate at 5 years after diagnosis was 61%. Histology grade, status of regional lymph node metastasis, distant metastasis and pathologic tumor stage were related to survival rate according to univariate analysis. Nevertheless, in multivariate analysis, only histology grade, distant metastasis and tumor size had influence on survival of colorectal cancer patients.

Conclusion: Generally the prognosis of disease is not poor; however, distant metastasis, poor differentiation and higher tumor size should be considered to have additional risks of death in colorectal cancer.


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© 2009, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.